1Dudhe S. A. ,  2Nikam A. V.

DOI : http://dx.doi.org/10.47191/ijahm/v12i4.02

 1Assistant Professor, Department of Agadtantra, Vyavhar Ayurved Evum Vidhivaidyak,Shri Ayurved Mahavidyalaya , Nagpur.

2Professor & HOD, Department of Agadtantra, Vyavhar Ayurved Evum Vidhivaidyak, Shri Ayurved Mahavidyalaya, Nagpur.

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ABSTRACT:

Human health is mainly depends on our surrounding environment. Arsenic is present in air, water, soil and food hence affecting many people across the world. Arsenic toxicity is now global health problem. The main source of arsenic toxicity is contaminated drinking water. In Ayurved Samhita Somala (Arsenic) is described as Sthawar Dhatu Visha.  Acharya Sushruta first described Somala as Dhatu Visha. In Rasashastra  Somala(Arsenic) is classified under Sadharana Rasa. Instead of highly toxic in nature Arsenic in proper dose act as medicine. It is use in many Ayurvedic medicinal preparations. Different compounds of Arsenic are used as insecticides, weedkiller, rodenticide, in flypaper, for sheep deep, as fruit spray, in medicine, as depilatory, colouring agent, and in industries. Arsenic trioxide is now used to treat acute promyelocytic leukaemia. Arsenic is mainly use to treat syphilis since ancient time. Arsenic is often used as a part of extremely diluted homeopathic remedies. Its improper medical use leads to accidental poisoning hence it should be take in proper doses. Arsenic is easily available and cheap hence it is use as homicidal agent in India. Inorganic Arsenic is carcinogenic to humans. Most of population get indirectly exposed to Arsenic as it is accumulates in rice plants in large quantity and in drinking water. This study is design to elaborate toxicological properties of Arsenic, its various sources of poisoning so that everyone should aware of its lethal effect on human being and its recent advances.  

Key words: Arsenic, Somala Dhatu, toxicological aspect, recent advances, sources.

 

REFERENCES:

  1. K. S. Narayan Reddy, Dr. O. P. Murty, The Essentials of Forensic Medicine and Toxicology, 33rd ed. New Delhi, Jaypee Brothers  Medical Publishers, 2014, 538.
  2. Ayurvedodharka Shaligram Vaishya. Shaligram Nighantu, Khemraj Shreekrushnadas, Vishvarga 797-807, Shree Venketeshwar press, Mumbai, 806.
  3. N. Ratnaik, Acute and chronic arsenic toxicity, Postgrad Medical Journal, 2003; Vol.79: 391-396.
  4. D. Pimparkar Aruna Bhave, Arsenocosis: A Review on Recent Advances, JAPI 2010; Vol. 58: 617-629.
  5. Jaising P. Modi, A Textbook of Medical Jurisprudence And Toxicology, 24th Haryana, Lexis Nexis(A division of Reed Elsevier India), 2012; 67.
  6. WHO (2019): Preventing disease through healthy environment, Exposure to arsenic: A Major public health concern, World Health Organisation, Geneva, https://apps.who.int/iris/rest/bitstreams/1257893/retriev
  7. Maharsi Sushruta, Sushrutsamhita, hindi commentary, vol 2 edited by Dr. Anant Ram Sharma, Kalpasthana, chapter 2, sloka 5, Varanasi, Chaukhamba Surbharti Prakashan; 2006, 518.
  8. Shri Vagbhatacharya, Rasratnasamuchchayah, Hindi Commentary, Vd. Shankarlal Harishankar, Chapter 3, sloka 120-121, Khemraj Shrikrushnasdas Prakashan, Mumbai, 2019, 83.
  9. Shastri Kashinath, Rastarangini, Tarang 11, Shloka 130-131, Motilal Banarasidas, Delhi, 11th edition 1979; 265.
  10. Shastri Kashinath, Rastarangini, Tarang 11, Shloka 130-131, Motilal Banarasidas, Delhi, 11th edition 1979; 265.
  11. Ayurvedodharka Shaligram Vaishya. Shaligram Nighantu, Khemraj Shreekrushnadas, Vishvarga 797-807, Shree Venketeshwar press, Mumbai; 806.
  12. Jaising P. Modi, A Textbook of Medical Jurisprudence And Toxicology, 24th Haryana, Lexis Nexis(A division of Reed Elsevier India), 2012, 67-71.
  13. UNICEF: Unicef policy brief: Mitigating Arsenic in Drinking water, 2018. Pg.1-6. https://www.unicef.org/wash/files/UNICEF_Mitigating_arsenic_in_drinking_water_policy_brief_2018.pdf
  14. Michael F Hughes et al, Arsenic Exposure and Toxicology: A Historical Perspective, Toxicological sciences, 123 (2); 2011: 305-332.
  15. WHO (2000): Air Quality Guidelines 2nd edition chapter 6.1, World Health Organization, Geneva, 125-127. https://www.euro.who.int/__data/assets/pdf_file/0014/123071/AQG2ndEd_6_1_Arsenic.PDF
  16. Zhu Y.G. et al. Exposure to inorganic arsenic from rice: A global health issue?, Environmental Pollution 2008; 1-3.
  17. Michael F Hughes et al, Arsenic Exposure and Toxicology: A Historical Perspective, Toxicological sciences, 2011; 123 (2): 305-332.
  18. WHO (2019): Preventing disease through healthy environment, Exposure to arsenic: A Major public health concern, World Health Organisation, Geneva, https://apps.who.int/iris/rest/bitstreams/1257893/retriev
  19. Wilson H. Miller, Jr., Hyman M. Schipper, Janet S. Lee, et al, Mechanismsof action of Arsenic Trioxide, Cancer Research, 2002; 62: 3893-3903.
  20. Jaising P. Modi, A Textbook of Medical Jurisprudence And Toxicology, 24th Haryana, Lexis Nexis(A division of Reed Elsevier India), 2012; 73.
  21. K. S. Narayan Reddy, Dr. O. P. Murty, The Essentials of Forensic Medicine and Toxicology, 33rd ed. New Delhi, Jaypee Brothers  Medical Publishers, 2014; 541.
  22. K. S. Narayan Reddy, Dr. O. P. Murty, The Essentials of Forensic Medicine and Toxicology, 33rd ed. New Delhi, Jaypee Brothers  Medical Publishers, 2014; 540.
  23. Apurba Nandy, Principles of Forensic Medicine Including Toxicology, 3rd Kolkata,New Central Book Agency; 2010, 775-776.                                                   
  24. Jaising P. Modi, A Textbook of Medical Jurisprudence And Toxicology, 24th Haryana, Lexis Nexis(A division of Reed Elsevier India), 2012, 77-78.
  25. C. K. Parikh, Textbook of Medical Jurisprudence, Forensic Medicine and Toxicology; 7th ed., Edited by B. V. Subrahmanyam; CBS Publishers & Disributors Pvt. Ltd, 2016, 570-571.
  26. Nrashant SinghDeepak KumarAnand P Sahu,   Arsenic in the environment: effects on human health and possible prevention, J. Environ Biol.  2007; 28(2): 359-65.
  27. Jaising P. Modi, A Textbook of Medical Jurisprudence And Toxicology, 24th Haryana, Lexis Nexis(A division of Reed Elsevier India), 2012, 79.
  28. Jomova, Z. Jenisova, M. Feszterova, S. Baros, J. Liska, D. Hudecova, C. J. Rhodesd, M. Valkoc,Arsenic: toxicity, oxidative stress and human ,Journal of  Applied Toxicology, 2011; 31: 95–107.
  29. Christopher States, Sanjay Srivastava, Yu Chen, Aaron Barchowsky, Arsenic and Cardiovascular Disease, Toxicologica l Sciences, 2009; 107(2): 312–323.
  30. A Vahidnia, GB van der Voet, FA de Wolff, Arsenic neurotoxicity – A review, Human & Experimental Toxicology, 2007;  26:  823–832.
  31. Debendra N Guha Muzumdar et al, Arsenic in drinking water and prevalence of respiratory effects in West Bengal, India, International Journal of Epidemiology, 2000; 29: 1047-1052.
  32. Simon Kapaj, Hans Peterson, Karsten Liber, Prosun Bhattacharya, Human Health Effects From Chronic Arsenic Poisoning– A Review, Journal of Environmental Science and Health Part A, 2006; 41: 2399–2428.
  33. Soile Tapio, Bernd Grosche, Arsenic in the aetiology of cancer, Review in Mutation Research, 2006; 612:215–246.
  34. D. Pimparkar Aruna Bhave, Arsenocosis: A Review on Recent Advances, JAPI, 2010; Vol. 58: 617-629.
  35. Amal Santra et al, Hepatic Damage Caused by Chronic Arsenic Toxicity in Experimental Animals, Journal of Toxicology: Clinical Toxicology, 2000; 38(4):  395-405