D. Mamatha*

Gland Institute of Pharmaceutical Sciences, Shangri-La, Kothapet (V), Sivampet (M) Near Narsapur, 

Medak (Dist.)-502110, Telangana State, India

ABSTRACT:-

The main aim of the work is to formulate and evaluate poly herbal anti diabetic tablets for medicinal purpose by using Momordica charantia, Mangifera indica, Carica papaya, Syzygium cumini leaves were collected from the local area, dried, powdered and extracted with ethanol separately and stored for further use. Tablets were prepared after preformulation studies and tablets were evaluated by using Weight variation, Hardness, Friability, Thickness and Disintegration Time.

Results: Prepared granules by wet granulation method were performed preformulation studies based on the preformulation studies powder flow properties are good and Weight variation was ± 5%, Hardness, Friability are respectively 3.5 ± 0.43 kg/cm2, 0.58 ± 0.05%. Thickness was measured as 3 ± 0.02 mm and Disintegration time 6 ± 0.32 min are good.

Discussion and Conclusion: Now a day’s Herbal medicines plays major role in the treatment than allopathic medicines because of less toxicity. Momordica charantia, Mangifera indica, Carica papaya, Syzygium cumini ethanolic extracts were used to formulate tablets. Based on the results it is clearly concluded that the prepared formulation of poly herbal antidiabetic tablets and evaluations are good.

 

Key words: poly herbal, Momordica charantia, Mangifera indica, Carica papaya,Syzygium cumini anti diabetic tablet,  Disintegration time.

Reference :

1.      Habibullah Khan M and Yadava PS. Antidiabetic plants used in Thobal district of Manipur, Northeast India, Indian journal of traditional knowledge, 2002; 9(3): 510-514.

2.      Anonymous, traditional medicine strategy. WHO, 2002-2005; WHO/EDM/TRM/2002.1.

3.      Patrick OE. Herbal medicines: challenges. Tropical J Pharmaceutics Res, 2005; 1(2): 53-54.

4.      Awadh A, Ali N, Al-rahwi IK and Lindequist U. Some medicinal plants used in Yemeni herbal to treat malaria. Afr J Traditional complement Alt Med., 2004; 1: 72-76.

5.      Kala CP. Ethno medicinal botany of the Apatani in the Eastern Himalayan region of India. J Ethnobiol Ethnomed, 2005; 1(11): 1-8.

6.      Grover JK and Vats V. Shifting Paradigm from conventional to alternate medicine. An introduction on traditional Indian medicine, Asia Pacific Biotechnology News, 2001

7.      Malik JK, Thacker AM and Ahmed A. Ethnoveterinary medicine in western India, Ethnoveterinary Research and Development, Edited by Mc Corkle C, (Intermediate Technology Publication, UK), 1996; 148.

8.      Kattamani KN, Munikrishnappa MP, Husain SA and Reddy PN. Use of plants as medicine under semi-arid tropical climate of Raichur district of North Karnataka, J Med Aromat Pl Sci, 2000; 22-23: 406-410.

9.      Tripathi YC. Ethno medical treasure of tribal Rajasthan, J Non Timbet Forest Product, 2000; 7(1/2): 77-84.

10.  Mukherjee SK and Mukherjee S. Therapeutic advances in Diabetes mellitus through ages. J Res Indian Med., 1966; 1-0: 9.

11.  Mehta KC. Indian herbal drugs in the treatment of diabetes. Current Med Pract. 1982; 26(10): 305.

12.  Aiman R. Recent research on indigenous antidiabetic medicinal plants an overall Assessment. Indian J Physiol & Pharmacol, 1970; 14(2): 65.

13.  Chaudhury RR and Vohora SB. Plants with possible hypoglycemic activity in advances in Research in Indian Medicine Udupa KN, Chaturvedi GN and Tripathi SN (Eds) Banaras Hindu University, Varanasi (India), 1970; 57.

14.  Karnick CR. Some aspects of crude Indian drugs plants used in Ayurvedic system of medicine (Madhumeha) (Dia betes). Acta Phytother Amst., 1972; 19: 141.

15.  Satyavati GV, Raina MK and Sharma M. Medicinal Plants of India, Indian Council of Medical Research, 1976; 1.

16.  Mukherjee SK. Indigenous drugs in Diabetes mellitus. J Diabetic Asso India, 1981

 

17.  Nagarajan S, Jain HC and Aulakh GS. Indigenous plants used in the control of Diabetes in Cultivation and Utilization of Medicinal Plants. Jammu regional research laboratory, 1982; 584-604.

18.  Satyavati GV. Pharmacology of medicinal plants and other natural products in Current Research in Pharmacology in India (1975-1982), Das PK and Dhawan BN (Eds), Indian National Science Academy New Delhi, 1984; 119-146.

19.  Patnaik GK and Dhawan BN. Pharmacological studies on Indian Medicinal plants in Current Research on Medicinal Plants in India. Dhawan BN (Ed) Indian National Science Academy New Delhi, 1986; 45.

20.  Das PK, Dasgupta G and Mishra AK. Clinical studies on Medicinal Plants of India in Current Research of Medicinal Plants in India. Dhawan BN (Ed), INSA New Delhi, 1986; 72.

21.  Satyavati GV, Gupta AK and Tandon N. Medicinal Plants of India, Indian Council of Medical Research New Delhi, 1987; 2.

22.  Sever BO. Oral hypoglycemic plants in West Africa. J Ethnopharmacol, 1980; 2: 109.

23.  Handa SS, Chawla AS and Maninder. Hypoglycemic plants - A review. Fitoterapia 1989; 60(3): 195.

24.  Atta-ur-Rahman and Khurshid Zaman. Medicinal plants with hypoglycemic activity. J Ethnopharmacol, 1989; 26(2): 1.

25.  Singhal PC and Joshi LD. Role of gum arabica and gum catechu in glycaemia and cholesterolemia. Curr Sci., 1984; 53: 91.

26.  WHO/Acadia, Rapport de la Journal International de, diabetes 1992; 14 October.

27.  ADA. Clinical practice recommendation 1997, Screening for diabetes. Diabetes care, 1997; 20(1): 22-24.

28.  Patel M, Jamrozik K, Allen O, Martin FI, Eng J and Dean B. A high prevalence of diabetes in a rural village in Papua New Guinea. Diabetes Research and Clinical Practice, 1986; 2(2): 97-103.

29.  Verma NP, Mehta SP, Madhu S, Mather, HM and Keen H. Prevalence of known diabetes in an urban Indian environment: the Darya Ganj diabetes survey. British Medical Journal, 1986; 293(6544): 423-424.

30.  Rao PV, Ushabala P, Seshiah V, Ahuja MM and Mather HM. The Eluru survey: prevalence of known diabetes in a rural Indian population. Diabetes Research and Clinical Practice, 1989; 7(1): 29-31

31.  Patel DK, Prasad SK, Kumar R and Hemalatha S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pacific Journal of Tropical Biomedicine, 2012; 320-330.

32.  Rawat Mukesh and Parmar Namita. American-Eurasian J Agric & Environ Sci., 2013; 13(1): 81-94.

33.  Aswini Kumar D and Sudurshan M. Review of flora of anti-diabetic plants of puducherry ut. International Journal of Applied Biology and Pharmaceutical Technology, 2011; 2(4): 455-462.

34.  Ayesha N, Vinay SB and Vijayalakshmi MA. Current update on anti-diabetic biomolecules from key traditional Indian medicinal plants. Current science, 2013; 104(6):

35.  Abdel NS, Fadia SY and Mohamed LA. Medicinal Plants with Potential Antidiabetic Activity and their Assessment. Med Aromat Plants, 2014; 3(1): 1-12.

36.  Rangari VD. Pharmacognosy and Phytochemistry, Nasik: Career Publications, 2002; 1st ed: 353-367.

37.  Trease GE and Evans WC. Pharmacognosy. London: environmental and. Land-based science, 1997; 14th ed: 340-408.

38.  Bruneton. Pharmacognosy and Phytochemistry Medicinal Plants. London: Intercept Ltd, 1999; 2nd ed: 310-354.

39.  Agarwal SS and Paridhavi M. Herbal drug technology. Hyderabad: University Press Private Limited, 2007; 663-671.

40.  Jain NK and Sharma SN. A Textbook of Professional Pharmacy. New Delhi: Vallabh Prakashan, 1998; 4th ed: 83-89.

41.  Cooper and Gunn. In: Tutorial Pharmacy, JB Publisher New Delhi 259.

42.  Harpreet S, Sudhanshu A, Munish M, Kamal KM and Phool C. Development of multicomponent formulation of herbal drugs for evaluation of Antidiabetic activity. Der Pharmacia Letter, 2014; 6(1): 219-223.

 

43.  Lechmann L, Lieberman HA and Kanig JL. The theory and Practice of Industrial Pharmacy Tablets, Varghese publishing house Bombay, 1991 4th edition 293-345.